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Hallmarks of aging: definition
The hallmarks of aging are a scientific framework describing the core biological processes that drive aging — updated in 2023 to twelve hallmarks.
Hallmarks of aging, explained
They include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation and dysbiosis.
Why it matters
The framework helps researchers — and you — understand why broad habits like exercise influence aging on multiple fronts.
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