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Genetics glossary

What is Folate?

Also known as: Vitamin B9.
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Quick answer

Folate: definition

Folate (vitamin B9) is a B vitamin essential for DNA synthesis, cell division and the methylation cycle; it's found naturally in leafy greens, legumes and other foods.

Folate, explained

Folic acid is the synthetic form used in supplements and fortified foods. The body converts folate forms into active 5-MTHF (methylfolate) with help from the MTHFR enzyme.

Adequate folate before and during early pregnancy reduces the risk of neural tube defects.

Why it matters

Folate status influences homocysteine and methylation — making it one of the most relevant nutrients for people with MTHFR variants.

Learn more

Genetics · GuideMethylation: What It Is, Why It Matters and How to Support ItWhat is methylation? A plain-English guide to the methylation cycle, the nutrients that power it (folate, B12, B6, choline), related genes like MTHFR and COMT, and how to support it.Genetics · GuideMTHFR: What the Gene Does, Common Variants and What Results MeanWhat is MTHFR? Learn what the gene does, how common the C677T and A1298C variants are, what results do and don't mean, folic acid vs. methylfolate, and smart next steps.Genetics · ComparisonMethylfolate vs. Folic Acid: Differences, MTHFR and Which to ChooseMethylfolate is active folate; folic acid is synthetic and needs conversion. Compare absorption, MTHFR considerations, pregnancy guidance and how to choose with your clinician.

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FAQ

Folate FAQs

What is Folate?

Folate (vitamin B9) is a B vitamin essential for DNA synthesis, cell division and the methylation cycle; it's found naturally in leafy greens, legumes and other foods.

Why does Folate matter?

Folate status influences homocysteine and methylation — making it one of the most relevant nutrients for people with MTHFR variants.

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