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Longevity glossary

What is NAD+?

Also known as: Nicotinamide adenine dinucleotide.
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Quick answer

NAD+: definition

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell that is essential for energy metabolism, DNA repair and the activity of sirtuin enzymes.

NAD+, explained

Research suggests NAD+ levels decline with age in some tissues. Precursors such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) raise NAD+ in human studies; evidence for meaningful health outcomes is still developing.

Why it matters

NAD+ is one of the most discussed molecules in longevity science — promising, but not yet proven as an anti-aging intervention.

Learn more

Longevity · GuideCellular Health: Mitochondria, NAD+, Autophagy and Aging CellsWhat is cellular health? A clear guide to mitochondria, NAD+, autophagy, oxidative stress and senescent cells — and the evidence-based ways to support healthy cells as you age.Longevity · HubLongevity: The Science of Living Longer, Stronger and BetterA science-informed guide to longevity: healthspan vs. lifespan, the hallmarks of aging, biological age, the habits with the strongest evidence, and which trends are still unproven.

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FAQ

NAD+ FAQs

What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell that is essential for energy metabolism, DNA repair and the activity of sirtuin enzymes.

Why does NAD+ matter?

NAD+ is one of the most discussed molecules in longevity science — promising, but not yet proven as an anti-aging intervention.

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