Quick answer
SAMe: definition
SAMe (S-adenosylmethionine) is the body's main methyl donor, made from the amino acid methionine and used in hundreds of methylation reactions.
SAMe, explained
After donating its methyl group, SAMe becomes SAH and then homocysteine, which is recycled back to methionine using folate and B12 or betaine.
Why it matters
SAMe sits at the center of the methylation cycle.
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What is SAMe?
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